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To explore mitochondrial dysfunction in Parkinson;s disease(PD)using P magnetic resonance spectroscopy of resting muscle.Case-control study(28 PD patients and 28 normal controls)determining resting forearm inorganic phosphate/phosphocreatinine(P/PCr ratio.Significant difference(p=0.004, one-tailed test)in P/PCr ratio between PD patients(0.122)and controls(0. 104).No correlation of P/PCr ration with duration,severity,or speed of onset of disease.Positive correlation of P/PCr ratio with age in control group;reversed in PD group.Suggests small generalized mitochondrial defect in PD.The possibility that earlier onset of disease is associated with more severe mitochondrial dysfunction needs further study. |
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